The primary affected person within the pilot episode is named Rebecca Adler after Irene Adler, a character within the first Holmes quick story, “A Scandal in Bohemia”. In the season two finale, House is shot by a crazed gunman credited as “Moriarty”, the name of Holmes’s nemesis. In the season 4 episode “It’s a Wonderful Lie”, House receives a “second-edition Conan Doyle” as a Christmas present. In the season five episode “The Itch”, House is seen picking up his keys and Vicodin from the highest of a copy of Conan Doyle’s The Memoirs of Sherlock Holmes. In one other season five episode, “Joy to the World”, House, in an try to fool his team, uses a e-book by Joseph Bell, Conan Doyle’s inspiration for Sherlock Holmes. Season 7 episode 3 features a younger adult boyhood detective guide sequence written by the affected person, whose ultimate unpublished quantity ends in an ambiguous end to the principle character reminiscent of “The Final Problem”.

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